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Folate Deficiency and MTHFR C677T Polymorphism Associated with Homocysteine

Paula Warner

A study epublished in January 2017 observed that the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and low levels of folate and vitamin B12 correlate with elevated serum total homocysteine (tHcy) levels. Increased tHcy has been associated with a number of health concerns including cardiovascular disease and dementia. People with the MTHFR C677T polymorphism inefficiently convert folic acid and other folate types into active 5-methyltetrahydrofolate (5-MTHF). This polymorphism has been linked to colon cancer, acute lymphoblastic leukemia, Alzheimer's disease, and recurrent pregnancy loss.

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Probiotics Possess Antiobesity Effects After High-Fat Diet

RICHARD WILLIAMS

Probiotics Possess Antiobesity Effects After High-Fat Diet

Probiotics Possess Antiobesity Effects After High-Fat Diet Probiotics counteract some of the damaging effects of a high-fat diet, researchers observed in a rodent study epublished in October 2016. Mice fed a high-fat diet for 8 weeks received one of the following probiotics: Lactobacillus casei IBS041, Lactobacillus acidophilus AD031, Bifidobacterium bifidum BGN4, or Bifidobacterium longum BORI. Supplementation with B. longum markedly inhibited weight gain without influencing food consumption and significantly reduced total cholesterol concentration in the liver. Hepatic triglyceride levels significantly declined in mice given L. acidophilus and B. bifidum. Furthermore, L. acidophilus and B. bifidumadministration markedly suppressed serum aspartate transaminase (AST) and alanine transaminase (ALT) levels. And administration of L. acidophilus, B. bifidum, and B. longum reduced hepatocyte hydropic degeneration...

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